CDA4b
- Norine ID: NOR00029
- DOI: 10.26097/nor00029
- Family: Calcium dependent antibiotic
- Synonym(s): CDA4b;
- Activity: antimicrobial
- Category: lipopeptide
- Formula:
- Comment: CDA shares a similar structure and possibly a related mode of action to other acidic lipopeptide antibiotics, including daptomycin, friulimicins, and amphomycins.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: partial cyclic
- Number of monomers: 12
- Smiles: CCCC7OC7(C(=O)NC(CO)C(=O)NC5C(C)OC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(CC(=O)O)NC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(Cc3c[nH]c4ccccc34)NC5(=O))c6ccc(O)cc6)C(O)C(N)=O)C(C)CC(=O)O)
- Graph inference:
- Monomeric composition :
1 C6:0-Ep(2) 2 Ser 3 Thr 4 D-Trp 5 Asp 6 Asp 7 D-Hpg 8 Asp 9 Gly 10 D-OH-Asn 11 3Me-Glu 12 Trp - Graph representation: C6:0-Ep(2),Ser,Thr,D-Trp,Asp,Asp,D-Hpg,Asp,Gly,D-OH-Asn,3Me-Glu,Trp @1 @0,2 @1,3,11 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @2,10
- Atomic structure:
- Streptomyces coelicolor
- gram: positive
- taxid: 100226 (view NCBI taxonomy browser)
- Streptomyces roseosporus
- gram: positive
- synonyms: Streptomyces filamentosus,Streptomyces venezuelae subsp. roseospori,Streptomyces roseisporus
- taxid: 67294 (view NCBI taxonomy browser)
- Alternaria brassicae
- gram:
- synonyms:
- taxid: 29911 (view NCBI taxonomy browser)
- Links between organisms producing the CDA4b: Streptomyces coelicolor, Streptomyces roseosporus, Alternaria brassicae
- Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor
Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J, Chemistry and biology , 2002, Nov,9(11):1175-87.
pubMed: 12445768
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