phakellistatin 8
- Norine ID: NOR00530
- DOI: 10.26097/nor00530
- Family: phakellistatin
- Synonym(s): phakellistatin 8;
- Activity: antitumor
- Category: peptide
- Formula: C61H88N10O11
- Monoisotopic mass: 1136.663403708 g/mol
- Comment: Phakellistatins are putative NRPS products (no synthetase genes identified)
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: putative - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: cyclic
- Number of monomers: 10
- Smiles: CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N3CCC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N4CCC[C@H]4C(=O)N5CCC[C@H]5C(=O)N1)[C@@H](C)CC)CC6=CC=C(C=C6)O)CC(C)C)C(C)C)CC7=CC=CC=C7
- Graph inference:
- Monomeric composition :
1 Pro 2 Tyr 3 Ile 4 Pro 5 Pro 6 Ile 7 Phe 8 Val 9 Leu 10 Pro - Graph representation: Pro,Tyr,Ile,Pro,Pro,Ile,Phe,Val,Leu,Pro @1,9 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @0,8
- Atomic structure:
- Phakellia sp.
- Links between organisms producing the phakellistatin 8: Phakellia sp.
- Isolation and structure of the human cancer cell growth inhibitory cyclic decapeptides phakellistatins 7,8 and 9
Pettit GR, Boyd MR, Cerny RL, Dorsaz AC, Williams MD, Xu JP, Bioorganic and medicinal chemistry letters , 1995, 5 (13), pp. 1339-1344
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