Norine

• Norine ID: NOR01092
• DOI: 10.26097/nor01092
• Family: zervamicin
• Synonym(s): zervamicin IIB;
• Activity: antimicrobial
• Category: peptaibol
• Formula: C90H139N19O22
• Monoisotopic mass: 1838.034207227 g/mol
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: linear
• Number of monomers: 16
• Smiles: CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@](C)(CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N1C[C@@H](C[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)NC(C)(C)C(=O)N2C[C@@H](C[C@H]2C(=O)NC(C)(C)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC4=CC=CC=C4)CO)O)O)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)C
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition and PDB SEQRES:

  gra 1 Ac-Trp 1 2 ACE TRP	2 Ile 3 ILE	3 Gln 4 GLN	4 D-Ival 5 DIV	5 Ile 6 ILE	6 Thr 7 THR	7 Aib 8 AIB	8 Leu 9 LEU	9 Aib 10 AIB	10 4OH-Pro 11 HYP	11 Gln 12 GLN	12 Aib 13 AIB
  13 4OH-Pro 14 HYP	14 Aib 15 AIB	15 Pro 16 PRO	16 Pheol 17 PHL

• Graph representation: Ac-Trp,Ile,Gln,D-Ival,Ile,Thr,Aib,Leu,Aib,4OH-Pro,Gln,Aib,4OH-Pro,Aib,Pro,Pheol @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @12,14 @13,15 @14
  
  
• Atomic structure:

vizualisation:

• Emericellopsis salmosynnemata
• taxid: 118885 (view NCBI taxonomy browser)

• Links between organisms producing the zervamicin IIB: Emericellopsis salmosynnemata

• Structures of eleven zervamicin and two emerimicin peptide antibiotics studied by fast atom bombardment mass spectrometry
  Rinehart KL, Cook JC, Pandey RC, Gaudioso LA, Moore ML, Barber M, Sedgwick RD, Bordoli RS, Tyler AN, Green BN, Journal of the American Chemical Society , 1981, 103 (21), pp 6517–6520
  

  1dlz 1r9u 1ih9

  1dlz 1r9u 1ih9

  1dlz 1r9u 1ih9