atroviridin C
- Norine ID: NOR00963
- DOI: 10.26097/nor00963
- Family: atroviridin
- Synonym(s): atroviridin C;
- Activity: antimicrobial
- Category: peptaibol
- Formula: C94H155N23O24
- Monoisotopic mass: 1990.1615330030002 g/mol
- Comment: They showed antimicrobial activity against Gram-positive bacteria and phytopathogenic fungi, and exhibited significant cytotoxicity to human cancer cell lines in vitro. Atroviridins showed significant membrane-perturbing activity responsible to their antibiotic action.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: linear
- Number of monomers: 20
- Smiles: CC[C@@](C)(C(=N[C@@H](CCC(=N)O)C(=N[C@@H](CCC(=N)O)C(=N[C@@H](CC1=CC=CC=C1)CO)O)O)O)N=C(C(C)(C)N=C([C@H](C(C)C)N=C([C@@H]2CCCN2C(=O)C(C)(C)N=C([C@H](CC(C)C)N=C(CN=C(C(C)(C)N=C([C@H](C(C)C)N=C(C(C)(C)N=C([C@H](CCC(=N)O)N=C(C(C)(C)N=C(C(C)(C)N=C([C@H](C)N=C(C(C)(C)N=C([C@@H]3CCCN3C(=O)C(C)(C)N=C(C)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O
- Graph inference:
- Monomeric composition :
1 Ac-Aib 2 Pro 3 Aib 4 Ala 5 Aib 6 Aib 7 Gln 8 Aib 9 Val 10 Aib 11 Gly 12 Leu 13 Aib 14 Pro 15 Val 16 Aib 17 Ival 18 Gln 19 Gln 20 Pheol - Graph representation: Ac-Aib,Pro,Aib,Ala,Aib,Aib,Gln,Aib,Val,Aib,Gly,Leu,Aib,Pro,Val,Aib,Ival,Gln,Gln,Pheol @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @12,14 @13,15 @14,16 @15,17 @16,18 @17,19 @18
- Atomic structure:
- Trichoderma atroviride
- taxid: 63577 (view NCBI taxonomy browser)
- Links between organisms producing the atroviridin C: Trichoderma atroviride
- Atroviridins A-C and neoatroviridins A-D, novel peptaibol antibiotics produced by Trichoderma atroviride F80317. I. Taxonomy, fermentation, isolation and biological activities
Oh SU, Yun BS, Lee SJ, Kim JH, Yoo ID, The Journal of antibiotics , 2002, Jun,55(6):557-64.
DOI: 10.7164/antibiotics.55.557
pubMed: 12195961
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