Norine

• Norine ID: NOR01093
• DOI: 10.26097/nor01093
• Family: zervamicin
• Synonym(s): Leu1-zervamicin;
• Activity: antimicrobial
• Category: peptaibol
• Formula: C85H140N18O22
• Monoisotopic mass: 1765.0389582540001 g/mol
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: linear
• Number of monomers: 16
• Smiles: CCC(C)C(NC(=O)C(CC(C)C)NC(C)=O)C(=O)NC(CCC(N)=O)C(=O)NC(C)(CC)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(C)(C)C(=O)NC(CC(C)C)C(=O)NC(C)(C)C(=O)N4CC(O)CC4(C(=O)NC(CCC(N)=O)C(=O)NC(C)(C)C(=O)N3CC(O)CC3(C(=O)NC(C)(C)C(=O)N2CCCC2(C(=O)NC(CO)Cc1ccccc1)))
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 NAc-Leu	2 Ile	3 Gln	4 D-Ival	5 Ile	6 Thr	7 Aib	8 Leu	9 Aib	10 4OH-Pro	11 Gln	12 Aib
  13 4OH-Pro	14 Aib	15 Pro	16 Pheol

• Graph representation: NAc-Leu,Ile,Gln,D-Ival,Ile,Thr,Aib,Leu,Aib,4OH-Pro,Gln,Aib,4OH-Pro,Aib,Pro,Pheol @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @12,14 @13,15 @14
  
  
• Atomic structure:

vizualisation:

• Emericellopsis salmosynnemata
• taxid: 118885 (view NCBI taxonomy browser)

• Links between organisms producing the Leu1-zervamicin: Emericellopsis salmosynnemata

• Crystal structure of [Leu1]zervamicin, a membrane ion-channel peptide: implications for gating mechanisms
  Flippen-Anderson JL, Karle IL, Balaram P, Agarwalla S, Proceedings of the National Academy of Sciences of the United States of America , 1991, Jun 15,88(12):5307-11.
  DOI: 10.1073/pnas.88.12.5307
  pubMed: 1711227

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