Norine

• Norine ID: NOR00375
• DOI: 10.26097/nor00375
• Family: didemnin
• Synonym(s): didemnin A;
• Activity: antimicrobial, antitumor, immunomodulating
• Category: peptide
• Formula: C49H78N6O12
• Monoisotopic mass: 942.56777199 g/mol
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: partial cyclic
• Number of monomers: 7
• Smiles: CCC(C)C2NC(=O)C(NC(=O)C(CC(C)C)NC)C(C)OC(=O)C(Cc1ccc(cc1)OC)N(C)C(=O)C3CCCN3(C(=O)C(CC(C)C)NC(=O)C(C)C(=O)C(OC(=O)CC2(O))C(C)C)
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 Ist

  2 Hip

  3 Leu

  4 Pro

  5 NMe-OMe-Tyr

  6 Thr

  7 D-NMe-Leu

• Graph representation: Ist,Hip,Leu,Pro,NMe-OMe-Tyr,Thr,D-NMe-Leu @1,5 @0,2 @1,3 @2,4 @3,5 @0,4,6 @5
  
  
• Atomic structure:

vizualisation:

• Trididemnum solidum
• gram:
• synonyms:
• taxid: 1079459 (view NCBI taxonomy browser)

• Didemnum sp.
• gram:
• synonyms:
• taxid: 107395 (view NCBI taxonomy browser)

• Links between organisms producing the didemnin A: Trididemnum solidum, Didemnum sp.

• Crystal and molecular structure of didemnin A, an antiviral depsipeptide
  Hossain MB, Van Der Helm D, Antel J, Sheldrick GM, Weinheimer AJ, Sanduja SK, International journal of peptide and protein research , 1996, Jan-Feb,47(1-2):20-7.
  DOI: 10.1111/j.1399-3011.1996.tb00805.x
  pubMed: 8907495

• Natural products as probes of cell biology: 20 years of didemnin research
  Vera MD, Joullie MM, Medicinal research reviews , 2002, Mar,22(2):102-45.
  pubMed: 11857636

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