Norine

• Norine ID: NOR00323
• DOI: 10.26097/nor00323
• Family: beauverolide
• Synonym(s): beauverolide La;
• Activity: unknown
• Category: lipopeptide
• Formula: C29H45N3O5
• Monoisotopic mass: 515.335921565 g/mol
• Comment: Recent studies have indicated that beauverolides could potentially serve as new drugs for the treatment of atherosclerosis.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: cyclic
• Number of monomers: 4
• Smiles: CCCCCCC(C)C1CC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)O1)[C@@H](C)CC)C)CC2=CC=CC=C2
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 C10:0-Me(4)-OH(3)

  2 Phe

  3 Ala

  4 D-aIle

• Graph representation: C10:0-Me(4)-OH(3),Phe,Ala,D-aIle @1,3 @0,2 @1,3 @0,2
  
  
• Atomic structure:

vizualisation:

• Beauveria vermiconia
• gram: n/a
• synonyms:
• taxid: 37996 (view NCBI taxonomy browser)

• Beauveria tenella
• taxid: 37999 (view NCBI taxonomy browser)

• Beauveria bassiana
• gram: n/a
• synonyms: Cordyceps bassiana,Tritirachium shiotae
• taxid: 176275 (view NCBI taxonomy browser)

• Paecilomyces fumosoroseus
• gram: n/a
• synonyms:
• taxid: 114497 (view NCBI taxonomy browser)

• Links between organisms producing the beauverolide La: Beauveria vermiconia, Beauveria tenella, Beauveria bassiana, Paecilomyces fumosoroseus

• Sequencing of new beauverolides by high-performance liquid chromatography and mass spectrometry
  Kuzma M, Jegorov A, Kacer P, Havlicek V, Journal of mass spectrometry , 2001, Oct,36(10):1108-15.
  DOI: 10.1002/jms.213
  pubMed: 11747104

• Extraribosomal cyclic tetradepsipeptides beauverolides: profiling and modeling the fragmentation pathways
  Kuzma M, Jegorov A, Havlicek V, Paizs B, Zabka M, Landa Z, Sulc M, Barrow MP, Journal of mass spectrometry , 2004, Aug,39(8):949-60.
  DOI: 10.1002/jms.674
  pubMed: 15329847

• Beauverolides L and La from Beauveria tenella and Paecilomyces fumosoroseus
  Jegorov A, Sedmera P, Matha V, Simek P, Zahradnickova H, Landa Z, Eyal J, Phytochemistry , 1994, Nov,37(5):1301-3.
  DOI: 10.1016/s0031-9422(00)90402-3
  pubMed: 7765754