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dolastatin 15


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  • Norine ID: NOR00370
  • DOI: 10.26097/nor00370
  • Family: dolastatin
  • Synonym(s): dolastatin 15;
  • Activity: antitumor
  • Category: peptide
  • Formula: C45H68N6O9
  • Monoisotopic mass: 836.504777804 g/mol
  • Comment: Potent inhibitor of the proliferation of murine and leukemia cell lines and also an inhibitor of hematopoietic progenitor cells. Also shown to inhibit microtubule assembly and to induce apoptosis and Bcl2 phosphorylation in many malignant cells types.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
  • Type: linear
  • Number of monomers: 7
  • Smiles: COC4=CC(=O)N(C(=O)C(OC(=O)C2CCCN2(C(=O)C1CCCN1(C(=O)C(C(C)C)N(C)C(=O)C(NC(=O)C(C(C)C)N(C)C)C(C)C)))C(C)C)C4(Cc3ccccc3)

  • Graph inference:



  • Monomeric composition :
    1
    Dov
    2
    Val
    3
    NMe-Val
    4
    Pro
    5
    Pro
    6
    Hiv
    7
    Dpy
  • Graph representation: Dov,Val,NMe-Val,Pro,Pro,Hiv,Dpy @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Dolabella auricularia
  • taxid: 6511 (view NCBI taxonomy browser)

  • Links between organisms producing the dolastatin 15: Dolabella auricularia


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