bergofungin A
- Norine ID: NOR00964
- DOI: 10.26097/nor00964
- Family: bergofungin
- Synonym(s):
- Activity: antimicrobial
- Category: peptaibol
- Formula: C73H120N16O19
- Monoisotopic mass: 1524.891565738 g/mol
- Comment:
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: linear
- Number of monomers: 15
- Smiles: CC[C@@](C)(C(=O)N1C[C@@H](C[C@H]1C(=O)NC(C)(C)C(=O)N[C@@H](CC2=CC=CC=C2)CO)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]3C[C@H](CN3C(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](C(C)C)NC(=O)C)O
- Graph inference:
- Monomeric composition :
1 Ac-Val 2 Aib 3 Aib 4 Aib 5 Val 6 Gly 7 Leu 8 Aib 9 Aib 10 4OH-Pro 11 Gln 12 Ival 13 4OH-Pro 14 Aib 15 Pheol - Graph representation: Ac-Val,Aib,Aib,Aib,Val,Gly,Leu,Aib,Aib,4OH-Pro,Gln,Ival,4OH-Pro,Aib,Pheol @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @12,14 @13
- Atomic structure:
- Emericellopsis donezkii
- gram:
- synonyms:
- taxid: 281368 (view NCBI taxonomy browser)
- Links between organisms producing the bergofungin A: Emericellopsis donezkii
- Isolation and structure of bergofungin, a new antifungal peptaibol from Emericellopsis donezkii HKI 0059
Ritzau M, Heinze S, Berg A, Schlegel B, Grafe U, Ihn W, Fleck WF, The Journal of antibiotics , 1996, Aug,49(8):817-20.
DOI: 10.7164/antibiotics.49.817
pubMed: 8823517
- A natural, single-residue substitution yields a less active peptaibiotic: the structure of bergofungin A at atomic resolution.
R. Gessmann, D. Axford, H. Brückner, A. Berg and K. Petratos, Acta Crystallographica. Section F, Structural Biology Communications , 2017, 73:95-100
DOI: 10.1107/S2053230X17001236
pubMed: 28177320
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