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dolastatin 12


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  • Norine ID: NOR00372
  • DOI: 10.26097/nor00372
  • Family: dolastatin
  • Synonym(s): dolastatin 12;
  • Activity: antitumor
  • Category: peptide
  • Formula: C50H80N8O11
  • Monoisotopic mass: 968.594655442 g/mol
  • Comment: Dolastatin 11 and dolastatin 12 inhibit growth of the murine P388 lymphocytic leukemia.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated - change status to non-NRP (Norine validators only)
    • last modification date: 2018-09-12 by Mickael Chevalier [Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
    • view all entry history
  • Type: cyclic
  • Number of monomers: 9
  • Smiles: CCC(C)C2OC(=O)C(C)C(CC)NC(=O)C(C)N(C)C(=O)C(C)(C)C(=O)C(C)NC(=O)C(Cc1ccccc1)N(C)C(=O)C(C(C)C)N(C)C(=O)CNC(=O)C(CC(C)C)N(C)C(=O)CNC2(=O)

  • Graph inference:



  • Monomeric composition :
    1
    Gly
    2
    NMe-Val
    3
    NMe-Tyr
    4
    Ibu
    5
    NMe-Ala
    6
    Map
    7
    Hmp
    8
    Gly
    9
    NMe-Leu
  • Graph representation: Gly,NMe-Val,NMe-Tyr,Ibu,NMe-Ala,Map,Hmp,Gly,NMe-Leu @1,8 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @0,7

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Dolabella auricularia
  • taxid: 6511 (view NCBI taxonomy browser)

  • Links between organisms producing the dolastatin 12: Dolabella auricularia
  • Dolastatins. 26. Synthesis and stereochemistry of dolastatin 11
    Bates RB, Brusoe KG, Burns JJ, Caldera S, Cui W, Gangwar S, Gramme MR, Bontems R, Journal of the American Chemical Society , 1997, 119 (9), pp. 2111-2113


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