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mycosubtilin 4


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  • Norine ID: NOR00222
  • DOI: 10.26097/nor00222
  • Family: iturin
  • Synonym(s): mycosubtilin 4;
  • Activity: surfactant, antimicrobial
  • Category: lipopeptide
  • Formula: C55H86N14O16
  • Monoisotopic mass: 1198.634622774 g/mol
  • Comment: The major components of mycosubtilin are iso C16 (29 %) and anteisoC17 (54 %) with small amounts of nC16 (6 %) and isoCl7 (7 %) beta-amino acids.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated - change status to non-NRP (Norine validators only)
    • last modification date: 2018-09-12 by Mickael Chevalier [Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
    • view all entry history
  • Type: cyclic
  • Number of monomers: 8
  • Smiles: CCC(C)CCCCCCCCCCC2CC(=O)NC(CC(N)=O)C(=O)NC(CCC(N)=O)C(=O)N3CCCC3(C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CC(N)=O)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NC(CC(N)=O)C(=O)N2)

  • Graph inference:



  • Monomeric composition :
    1
    aC17:0-NH2(3)
    2
    Asn
    3
    D-Tyr
    4
    D-Asn
    5
    Gln
    6
    Pro
    7
    D-Ser
    8
    Asn
  • Graph representation: aC17:0-NH2(3),Asn,D-Tyr,D-Asn,Gln,Pro,D-Ser,Asn @1,7 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @0,6

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Bacillus subtilis
  • gram: positive
  • synonyms: Bacillus uniflagellatus,Bacillus natto,Bacillus globigii,Vibrio subtilis
  • taxid: 1423 (view NCBI taxonomy browser)

  • Links between organisms producing the mycosubtilin 4: Bacillus subtilis
  • The mycosubtilin synthetase of Bacillus subtilis ATCC6633: a multifunctional hybrid between a peptide synthetase, an amino transferase, and a fatty acid synthase
    Vater J, Ullrich C, Duitman EH, Hamoen LW, Rembold M, Venema G, Seitz H, Saenger W, Bernhard F, Reinhardt R, Schmidt M, Stein T, Leenders F, Proceedings of the National Academy of Sciences of the United States of America , 1999, Nov 9,96(23):13294-9.
    DOI: 10.1073/pnas.96.23.13294
    pubMed: 10557314


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