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feglymycin


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  • Norine ID: NOR01081
  • DOI: 10.26097/nor01081
  • Family: feglymycin
  • Synonym(s): feglymycin;
  • Activity: antimicrobial
  • Category: peptide
  • Formula: C95H97N13O30
  • Monoisotopic mass: 1899.646428829 g/mol
  • Comment: As well as having weak antibacterial activity, feglymycin inhibits the replication of the human immunodeficiency virus (HIV) in vitro.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
  • Type: linear
  • Number of monomers: 13
  • Smiles: CC(C)C(NC(=O)C(NC(=O)C(N)c1ccc(O)cc1)c2cc(O)cc(O)c2)C(=O)NC(c3cc(O)cc(O)c3)C(=O)NC(c4ccc(O)cc4)C(=O)NC(c5cc(O)cc(O)c5)C(=O)NC(c6ccc(O)cc6)C(=O)NC(c7cc(O)cc(O)c7)C(=O)NC(C(C)C)C(=O)NC(c8cc(O)cc(O)c8)C(=O)NC(c9ccc(O)cc9)C(=O)NC(Cc%10ccccc%10)C(=O)NC(CC(=O)O)C(=O)O

  • Graph inference:



  • Monomeric composition and PDB SEQRES:
    1
    D-Hpg
    1
    GHP
    2
    D-Dhpg
    2
    D3P
    3
    Val
    3
    VAL
    4
    D-Dhpg
    4
    D3P
    5
    Hpg
    5
    D4P
    6
    D-Dhpg
    6
    D3P
    7
    Hpg
    7
    D4P
    8
    D-Dhpg
    8
    D3P
    9
    Val
    9
    VAL
    10
    D-Dhpg
    10
    D3P
    11
    Hpg
    11
    D4P
    12
    Phe
    12
    PHE
    13
    Asp
    13
    ASP
  • Graph representation: D-Hpg,D-Dhpg,Val,D-Dhpg,Hpg,D-Dhpg,Hpg,D-Dhpg,Val,D-Dhpg,Hpg,Phe,Asp @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11

  • Atomic structure:
    • Chemical structure
    rBAN vizualisation:
  • Streptomyces sp. DSM 11171
  • gram: positive
  • taxid: 1740725 (view NCBI taxonomy browser)

  • Links between organisms producing the feglymycin: Streptomyces sp. DSM 11171
  • Feglymycin, a novel inhibitor of the replication of the human immunodeficiency virus. Fermentation, isolation and structure elucidation
    Vertesy L, Vogel M, Wink J, Aretz W, Knauf M, Markus A, The Journal of antibiotics , 1999, Apr,52(4):374-82.
    DOI: 10.7164/antibiotics.52.374
    pubMed: 10395273


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