Norine

• Norine ID: NOR00692
• DOI: 10.26097/nor00692
• Family: decaplanin
• Synonym(s): decaplanin;
• Activity: antimicrobial
• Category: glycopeptide
• Formula: C72H86ClN9O28
• Monoisotopic mass: 1559.5270809229999 g/mol
• Comment: Two bonds of the central Hpg are due to oxidative ring closure.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: other
• Number of monomers: 10
• Smiles: CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C(C(=O)NC(C(=O)NC5C(=O)NC7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9C(NC(=O)C(C(C1=CC=C(O4)C=C1)OC1CC(C(C(O1)C)O)(C)N)NC7=O)C(=O)O)O)O)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)CO)O)O)O)O)O
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 Asn

  2 bOH-Cl-Tyr

  3 NMe-Leu

  4 Hpg

  5 D-Glc

  6 Rha

  7 bOH-Tyr

  8 Ere

  9 Dhpg

  10 Hpg

• Graph representation: Asn,bOH-Cl-Tyr,NMe-Leu,Hpg,D-Glc,Rha,bOH-Tyr,Ere,Dhpg,Hpg @1,3 @0,2,3 @1 @1,0,4,6,9 @3,5 @4 @3,8,7,9 @6 @6,9 @8,3,6
  
  
• Atomic structure:

vizualisation:

• Nocardia orientalis
• gram: positive
• synonyms: Amycolatopsis orientalis,Streptomyces orientalis,Amycolatopsis orientalis orientalis
• taxid: 31958 (view NCBI taxonomy browser)

• Kibdellosporangium deccaensis
• gram: positive
• synonyms: Kibdelosporangium deccaensis

• Links between organisms producing the decaplanin: Nocardia orientalis, Kibdellosporangium deccaensis

• In vitro activity of decaplanin (M86-1410), a new glycopeptide antibiotic
  Sanchez ML, Wenzel RP, Jones RN, Antimicrobial agents and chemotherapy , 1992, Apr,36(4):873-5.
  DOI: 10.1128/aac.36.4.873
  pubMed: 1386973

  195570

  BGC0001460 BGC0001459