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kahalalide A


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  • Norine ID: NOR00391
  • DOI: 10.26097/nor00391
  • Family: kahalalide
  • Synonym(s): kahalalide A;
  • Activity: antimicrobial
  • Category: peptide
  • Formula: C46H67N7O11
  • Monoisotopic mass: 893.4898560209999 g/mol
  • Comment: Kahalalide A and F from Bryopsis sp. were noted for their in vitro activity against Mycobacterium tuberculosis
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
  • Type: partial cyclic
  • Number of monomers: 8
  • Smiles: CCC(C)C(=O)NC(Cc1ccccc1)C(=O)NC3C(=O)NC(CC(C)C)C(=O)NC(Cc2ccccc2)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)OC3(C)

  • Graph inference:



  • Monomeric composition :
    1
    C4:0-Me(2)
    2
    D-Phe
    3
    Thr
    4
    D-Leu
    5
    D-Phe
    6
    D-Leu
    7
    Thr
    8
    Ser
  • Graph representation: C4:0-Me(2),D-Phe,Thr,D-Leu,D-Phe,D-Leu,Thr,Ser @1 @0,2 @1,3,7 @2,4 @3,5 @4,6 @5,7 @2,6

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Elysia rufescens
  • taxid: 380559 (view NCBI taxonomy browser)

  • Bryopsis pennata
  • taxid: 381411 (view NCBI taxonomy browser)

  • Links between organisms producing the kahalalide A: Elysia rufescens, Bryopsis pennata
  • Solid-phase total synthesis of kahalalide A and related analogues
    Bourel-Bonnet L, Rao KV, Hamann MT, Ganesan A, Journal of medicinal chemistry , 2005, Mar 10,48(5):1330-5.
    DOI: 10.1021/jm049841x
    pubMed: 15743176


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