Norine

• Norine ID: NOR01128
• DOI: 10.26097/nor01128
• Family: quinomycin
• Synonym(s): quinomycin C;
• Activity: antimicrobial, antitumor
• Category: peptide
• Formula: C55H72N12O12S2
• Monoisotopic mass: 1156.483407228 g/mol
• Comment: Quinomycins contain a thioacetal cross bridge. In the tiostin analogues, a disulfide bond replaces the thioacetal cross-link.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: partial cyclic
• Number of monomers: 10
• Smiles: CC(C)C(C)C6C(=O)OCC(NC(=O)c1cnc2ccccc2(n1))C(=O)NC(C)C(=O)N(C)C5C(=O)N(C)C(C(C)C(C)C)C(=O)OCC(NC(=O)c3cnc4ccccc4(n3))C(=O)NC(C)C(=O)N(C)C(CSC5SC)C(=O)N6(C)
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 COOH-Qui

  2 D-Ser

  3 Ala

  4 diMe-Cys

  5 diMe-aIle

  6 D-Ser

  7 COOH-Qui

  8 Ala

  9 NMe-Cys

  10 diMe-aIle

• Graph representation: COOH-Qui,D-Ser,Ala,diMe-Cys,diMe-aIle,D-Ser,COOH-Qui,Ala,NMe-Cys,diMe-aIle @1 @0,2,9 @1,3 @2,4,8 @3,5 @4,6,7 @5 @5,8 @3,7,9 @1,8
  
  
• Atomic structure:

vizualisation:

• Streptomyces sp.
• gram: positive
• synonyms:
• taxid: 1931 (view NCBI taxonomy browser)

• Links between organisms producing the quinomycin C: Streptomyces sp.

• Structure of quinomycin antibiotics
  Martin DG, Mizsak SA, Biles C, Stewart JC, Bacynsky L, Meulman PA, The Journal of antibiotics , 1975, Apr,28(4):332-6.
  DOI: 10.7164/antibiotics.28.332
  pubMed: 1150534

  197124