Norine

• Norine ID: NOR00369
• DOI: 10.26097/nor00369
• Family: dolastatin
• Synonym(s): dolastatin 10;
• Activity: antitumor
• Category: peptide
• Formula: C42H68N6O6S
• Monoisotopic mass: 784.492104638 g/mol
• Comment: dolastatin 10 is an anticancer natural product, microtubule destabilizing agent
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: linear
• Number of monomers: 5
• Smiles: CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C3=NC=CS3)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 Dov

  2 Val

  3 Dil

  4 Dap

  5 Doe

• Graph representation: Dov,Val,Dil,Dap,Doe @1 @0,2 @1,3 @2,4 @3
  
  
• Atomic structure:

vizualisation:

• Dolabella auricularia
• taxid: 6511 (view NCBI taxonomy browser)

• Symploca sp. VP642
• gram: negative
• taxid: 162626 (view NCBI taxonomy browser)

• Links between organisms producing the dolastatin 10: Dolabella auricularia, Symploca sp. VP642

• Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1
  Luesch H, Moore RE, Paul VJ, Mooberry SL, Corbett TH, Journal of natural products , 2001, Jul,64(7):907-10.
  DOI: 10.1021/np010049y
  pubMed: 11473421

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