decaplanin
- Norine ID: NOR00692
- DOI: 10.26097/nor00692
- Family: decaplanin
- Synonym(s): decaplanin;
- Activity: antimicrobial
- Category: glycopeptide
- Formula: C72H86ClN9O28
- Monoisotopic mass: 1559.527080923 g/mol
- Comment: Two bonds of the central Hpg are due to oxidative ring closure.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: other
- Number of monomers: 10
- Smiles: CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C(C(=O)NC(C(=O)NC5C(=O)NC7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9C(NC(=O)C(C(C1=CC=C(O4)C=C1)OC1CC(C(C(O1)C)O)(C)N)NC7=O)C(=O)O)O)O)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)CO)O)O)O)O)O
- Graph inference:
- Monomeric composition :
1 Asn 2 bOH-Cl-Tyr 3 NMe-Leu 4 Hpg 5 D-Glc 6 Rha 7 bOH-Tyr 8 Ere 9 Dhpg 10 Hpg - Graph representation: Asn,bOH-Cl-Tyr,NMe-Leu,Hpg,D-Glc,Rha,bOH-Tyr,Ere,Dhpg,Hpg @1,3 @0,2,3 @1 @1,0,4,6,9 @3,5 @4 @3,8,7,9 @6 @6,9 @8,3,6
- Atomic structure:
- Nocardia orientalis
- gram: positive
- synonyms: Amycolatopsis orientalis,Streptomyces orientalis,Amycolatopsis orientalis orientalis
- taxid: 31958 (view NCBI taxonomy browser)
- Kibdellosporangium deccaensis
- gram: positive
- synonyms: Kibdelosporangium deccaensis
- Links between organisms producing the decaplanin: Nocardia orientalis, Kibdellosporangium deccaensis
- In vitro activity of decaplanin (M86-1410), a new glycopeptide antibiotic
Sanchez ML, Wenzel RP, Jones RN, Antimicrobial agents and chemotherapy , 1992, Apr,36(4):873-5.
DOI: 10.1128/aac.36.4.873
pubMed: 1386973
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