kahalalide A
- Norine ID: NOR00391
- DOI: 10.26097/nor00391
- Family: kahalalide
- Synonym(s): kahalalide A;
- Activity: antimicrobial
- Category: peptide
- Formula: C46H67N7O11
- Monoisotopic mass: 893.489856021 g/mol
- Comment: Kahalalide A and F from Bryopsis sp. were noted for their in vitro activity against Mycobacterium tuberculosis
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: partial cyclic
- Number of monomers: 8
- Smiles: CCC(C)C(=O)NC(Cc1ccccc1)C(=O)NC3C(=O)NC(CC(C)C)C(=O)NC(Cc2ccccc2)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)OC3(C)
- Graph inference:
- Monomeric composition :
1 C4:0-Me(2) 2 D-Phe 3 Thr 4 D-Leu 5 D-Phe 6 D-Leu 7 Thr 8 Ser - Graph representation: C4:0-Me(2),D-Phe,Thr,D-Leu,D-Phe,D-Leu,Thr,Ser @1 @0,2 @1,3,7 @2,4 @3,5 @4,6 @5,7 @2,6
- Atomic structure:
- Elysia rufescens
- taxid: 380559 (view NCBI taxonomy browser)
- Bryopsis pennata
- taxid: 381411 (view NCBI taxonomy browser)
- Links between organisms producing the kahalalide A: Elysia rufescens, Bryopsis pennata
- Solid-phase total synthesis of kahalalide A and related analogues
Bourel-Bonnet L, Rao KV, Hamann MT, Ganesan A, Journal of medicinal chemistry , 2005, Mar 10,48(5):1330-5.
DOI: 10.1021/jm049841x
pubMed: 15743176
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