Norine

• Norine ID: NOR00693
• DOI: 10.26097/nor00693
• Family: eremomycin
• Synonym(s): eremomycin;
• Activity: antimicrobial
• Category: glycopeptide
• Formula: C73H89ClN10O26
• Monoisotopic mass: 1556.56380078 g/mol
• Comment: Two bonds of the central Hpg are due to oxidative ring closure.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: other
• Number of monomers: 10
• Smiles: CNC(CC(C)C)C(=O)NC%11C(=O)NC(CC(N)=O)C(=O)NC3c9cc(Oc1ccc(cc1)C(OC2CC(C)(N)C(O)C(C)O2)C5NC(=O)C(NC3(=O))c4ccc(O)c(c4)c6c(O)cc(O)cc6(C(NC5(=O))C(=O)O))c(OC8OC(CO)C(O)C(O)C8(OC7CC(C)(N)C(O)C(C)O7))c(c9)Oc%10ccc(cc%10Cl)C%11(O)
  
  
• Graph inference:


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• Monomeric composition :

  1 Asn

  2 bOH-Cl-Tyr

  3 NMe-Leu

  4 Hpg

  5 D-Glc

  6 Ere

  7 bOH-Tyr

  8 Ere

  9 Dhpg

  10 Hpg

• Graph representation: Asn,bOH-Cl-Tyr,NMe-Leu,Hpg,D-Glc,Ere,bOH-Tyr,Ere,Dhpg,Hpg @1,3 @0,2,3 @1 @1,0,4,6,9 @3,5 @4 @3,8,7,9 @6 @6,9 @8,3,6
  
  
• Atomic structure:

vizualisation:

• actinomycetes sp. INA 238
• gram: positive

• Links between organisms producing the eremomycin: actinomycetes sp. INA 238

• Eremomycin:new glycopeptide antibiotic: chemical properties and structure
  Gause GF, Brazhnikova MG, Lomakina NN, Berdnikova TF, Fedorova GB, Tokareva NL, Borisova VN, Batta GY, The Journal of antibiotics , 1989, Dec,42(12):1790-7.
  DOI: 10.7164/antibiotics.42.1790
  pubMed: 2621162

  122131

  CHEMBL411769