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cyclotheonamide E4


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  • Norine ID: NOR00478
  • DOI: 10.26097/nor00478
  • Family: cyclotheonamide
  • Synonym(s): cyclotheonamide E4;
  • Activity: antithrombotic
  • Category: peptide
  • Formula: C41H62N10O9
  • Monoisotopic mass: 838.4701236320001 g/mol
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
  • Type: partial cyclic
  • Number of monomers: 7
  • Smiles: CC[C@@H](C)[C@H]1C(=O)N[C@H](/C=C/C(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)C(=O)N1)CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)CC(C)CC)CC3=CC=C(C=C3)O

  • Graph inference:



  • Monomeric composition :
    1
    Pro
    2
    k-Arg
    3
    D-aIle
    4
    v-Tyr
    5
    Dpr
    6
    Ala
    7
    Me-Vaa
  • Graph representation: Pro,k-Arg,D-aIle,v-Tyr,Dpr,Ala,Me-Vaa @1,4 @0,2 @1,3 @2,4 @0,3,5 @4,6 @5

  • Atomic structure:
    • Chemical structure
    rBAN vizualisation:
  • Ircinia
  • taxid: 275431 (view NCBI taxonomy browser)

  • Links between organisms producing the cyclotheonamide E4: Ircinia
  • Cyclotheonamide E4 and E5, new potent tryptase inhibitors from an Ircinia species of sponge
    Murakami Y, Takei M, Shindo K, Kitazume C, Tanaka J, Higa T, Fukamachi H, Journal of natural products , 2002, Mar,65(3):259-61.
    DOI: 10.1021/np010304e
    pubMed: 11908961


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