Norine

• Norine ID: NOR00391
• DOI: 10.26097/nor00391
• Family: kahalalide
• Synonym(s): kahalalide A;
• Activity: antimicrobial
• Category: peptide
• Formula: C46H67N7O11
• Monoisotopic mass: 893.4898560209999 g/mol
• Comment: Kahalalide A and F from Bryopsis sp. were noted for their in vitro activity against Mycobacterium tuberculosis
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: partial cyclic
• Number of monomers: 8
• Smiles: CCC(C)C(=O)NC(Cc1ccccc1)C(=O)NC3C(=O)NC(CC(C)C)C(=O)NC(Cc2ccccc2)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)OC3(C)
  
  
• Graph inference:


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• Monomeric composition :

  1 C4:0-Me(2)

  2 D-Phe

  3 Thr

  4 D-Leu

  5 D-Phe

  6 D-Leu

  7 Thr

  8 Ser

• Graph representation: C4:0-Me(2),D-Phe,Thr,D-Leu,D-Phe,D-Leu,Thr,Ser @1 @0,2 @1,3,7 @2,4 @3,5 @4,6 @5,7 @2,6
  
  
• Atomic structure:

vizualisation:

• Elysia rufescens
• taxid: 380559 (view NCBI taxonomy browser)

• Bryopsis pennata
• taxid: 381411 (view NCBI taxonomy browser)

• Links between organisms producing the kahalalide A: Elysia rufescens, Bryopsis pennata

• Solid-phase total synthesis of kahalalide A and related analogues
  Bourel-Bonnet L, Rao KV, Hamann MT, Ganesan A, Journal of medicinal chemistry , 2005, Mar 10,48(5):1330-5.
  DOI: 10.1021/jm049841x
  pubMed: 15743176

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