onchidin
- Norine ID: NOR00430
- DOI: 10.26097/nor00430
- Family: onchidin
- Synonym(s): onchidin;
- Activity: toxin
- Category: peptide
- Formula: C60H99N6O14
- Monoisotopic mass: 1127.721926906 g/mol
- Comment: onchidin is a putative NRPS product (no synthetase genes identified).
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: putative - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: cyclic
- Number of monomers: 10
- Smiles: C[C@@H]1[C@H](NC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@H](OC(=O)[C@H](N(C(=O)[C@H]([C@@H](NC(=O)C(NC(=O)[C@H](OC(=O)[C@H](OC(=O)[C@H](N(C1=O)C)C(C)C)C(C)C)C(C)C)C(C)C)CCCC#C)C)C)C(C)C)C(C)C)C(C)C)C(C)C)CCCC#C
- Graph inference:
- Monomeric composition :
1 NMe-Val 2 C8:0:1(7)-Me(2)-NH2(3) 3 Val 4 Hiv 5 Hiv 6 NMe-Val 7 C8:0:1(7)-Me(2)-NH2(3) 8 Val 9 Hiv 10 Hiv - Graph representation: NMe-Val,C8:0:1(7)-Me(2)-NH2(3),Val,Hiv,Hiv,NMe-Val,C8:0:1(7)-Me(2)-NH2(3),Val,Hiv,Hiv @1,9 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @0,8
- Atomic structure:
- Onchidium sp.
- taxid: 69682 (view NCBI taxonomy browser)
- Links between organisms producing the onchidin: Onchidium sp.
- Onchidin: a cytotoxic depsipeptide with C2 symmetry from a marine mollusc
Debitus C, Rodriguez J, Fernandez R, Quinoa E, Riguera R, Bouchet P, Tetrahedron letters , 1994, 35 (49), pp. 9239-9242
- Toward the total synthesis of onchidin, a cytotoxic cyclic depsipeptide from a mollusc
Kobayashi S, Kobayashi J, Yazaki R, Ueno M, Chemistry, an Asian journal , 2007, Jan 8,2(1):135-44.
DOI: 10.1002/asia.200600232
pubMed: 17441146
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