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vancomycin


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  • Norine ID: NOR00681
  • DOI: 10.26097/nor00681
  • Family: vancomycin
  • Synonym(s): vancomycin;
  • Activity: antimicrobial
  • Category: glycopeptide
  • Formula: C66H75Cl2N9O24
  • Monoisotopic mass: 1447.4301997930002 g/mol
  • Comment: Vancomycin is a glycopeptide antibiotic used in the prophylaxis and treatment of infections caused by Gram-positive bacteria. It has traditionally been reserved as a drug of "last resort", used only after treatment with other antibiotics had failed, although the emergence of vancomycin-resistant organisms means that it is increasingly being displaced from this role by linezolid and the carbapenems. Two bonds of the central Hpg are due to oxidative ring closure reactions.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
  • Type: other
  • Number of monomers: 9
  • Smiles: C[C@H]1[C@H]([C@@](C[C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9[C@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)(C)N)O

  • Graph inference:



  • Monomeric composition :
    1
    Asn
    2
    bOH-Cl-Tyr
    3
    NMe-Leu
    4
    Hpg
    5
    D-Glc
    6
    Van
    7
    bOH-Cl-Tyr
    8
    Dhpg
    9
    Hpg
  • Graph representation: Asn,bOH-Cl-Tyr,NMe-Leu,Hpg,D-Glc,Van,bOH-Cl-Tyr,Dhpg,Hpg @1,3 @0,2,3 @1 @1,0,4,6,8 @3,5 @4 @3,7,8 @6,8 @3,7,6

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Nocardia orientalis
  • gram: positive
  • synonyms: Amycolatopsis orientalis,Streptomyces orientalis,Amycolatopsis orientalis orientalis
  • taxid: 31958 (view NCBI taxonomy browser)

  • Links between organisms producing the vancomycin: Nocardia orientalis


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