callipeltin A
- Norine ID: NOR00417
- DOI: 10.26097/nor00417
- Family: callipeltin
- Synonym(s): callipeltin A;
- Activity: antimicrobial, toxin
- Category: lipopeptide
- Formula: C68H116N18O20
- Monoisotopic mass: 1504.8613282420001 g/mol
- Comment: Callipeltin is a putative NRPS product (no synthetase genes identified).
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: putative - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: partial cyclic
- Number of monomers: 11
- Smiles: COC(c1ccc(O)cc1)C2NC(=O)C(CCC(N)=O)N(C)C(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(O)C(O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(C)C(O)C(C)CC(C)C)C(C)C(C)C(N)=O)C(C)OC(=O)C(C)N(C)C2(=O))C(C)O
- Graph inference:
- Monomeric composition :
1 iC8:0-Me(2.4)-OH(3) 2 D-Ala 3 Agdha 4 3Me-4Me-Gln 5 D-aThr 6 D-aThr 7 D-Arg 8 Leu 9 NMe-Gln 10 bOMe-Tyr 11 NMe-Ala - Graph representation: iC8:0-Me(2.4)-OH(3),D-Ala,Agdha,3Me-4Me-Gln,D-aThr,D-aThr,D-Arg,Leu,NMe-Gln,bOMe-Tyr,NMe-Ala @1 @0,2 @1,3 @2,4 @3,5,10 @4,6 @5,7 @6,8 @7,9 @8,10 @4,9
- Atomic structure:
- Callipelta sp.
- Latrunculia sp.
- Links between organisms producing the callipeltin A: Callipelta sp., Latrunculia sp.
- Callipeltin A, a cyclic depsipeptide inhibitor of the cardiac sodium-calcium exchanger and positive inotropic agent
Trevisi L, Bova S, Cargnelli G, Danieli-Betto D, Floreani M, Germinario E, D Auria MV, Luciani S, Biochemical and biophysical research communications , 2000, Dec 9,279(1):219-22.
DOI: 10.1006/bbrc.2000.3906
pubMed: 11112442
- Isolation of callipeltins A-C and of two new open-chain derivatives of callipeltin A from the marine sponge Latrunculia sp. A revision of the stereostructure of callipeltins
Trevisi L, D Auria MV, Luciani S, Zampella A, Debitus C, Randazzo A, Borbone N, Tetrahedron letters , 2002, 43 (35), pp. 6163-6166
- Solid-phase synthesis and configurational reassigment of callipeltin E. Implications for the structures of callipeltins A and B
Calimsiz S, Morales Ramos AI, Lipton MA, The Journal of organic chemistry , 2006, 18,71(17):6351-6.
DOI: 10.1021/jo060351h
pubMed: 16901115
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