Norine

• Norine ID: NOR00326
• DOI: 10.26097/nor00326
• Family: beauverolide
• Synonym(s):
• Activity: antiatherogenic
• Category: lipopeptide
• Formula: C27H41N3O5
• Monoisotopic mass: 487.304621437 g/mol
• Comment: Recent studies have indicated that beauverolides could potentially serve as new drugs for the treatment of atherosclerosis.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: cyclic
• Number of monomers: 4
• Smiles: CCCCC(C)C1CC(=O)NC(CC2=CC=CC=C2)C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)O1
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 C8:0-Me(4)-OH(3)

  2 Phe

  3 Ala

  4 D-Leu

• Graph representation: C8:0-Me(4)-OH(3),Phe,Ala,D-Leu @1,3 @0,2 @1,3 @0,2
  
  
• Atomic structure:

vizualisation:

• Beauveria vermiconia
• gram: n/a
• synonyms:
• taxid: 37996 (view NCBI taxonomy browser)

• Beauveria bassiana
• gram: n/a
• synonyms: Cordyceps bassiana,Tritirachium shiotae
• taxid: 176275 (view NCBI taxonomy browser)

• Paecilomyces fumosoroseus
• gram: n/a
• synonyms:
• taxid: 114497 (view NCBI taxonomy browser)

• Links between organisms producing the beauverolide I: Beauveria vermiconia, Beauveria bassiana, Paecilomyces fumosoroseus

• Sequencing of new beauverolides by high-performance liquid chromatography and mass spectrometry
  Kuzma M, Jegorov A, Kacer P, Havlicek V, Journal of mass spectrometry , 2001, Oct,36(10):1108-15.
  DOI: 10.1002/jms.213
  pubMed: 11747104

• Extraribosomal cyclic tetradepsipeptides beauverolides: profiling and modeling the fragmentation pathways
  Kuzma M, Jegorov A, Havlicek V, Paizs B, Zabka M, Landa Z, Sulc M, Barrow MP, Journal of mass spectrometry , 2004, Aug,39(8):949-60.
  DOI: 10.1002/jms.674
  pubMed: 15329847

• Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophages
  Namatame I, Tomoda H, Ishibashi S, Omura S, Proceedings of the National Academy of Sciences of the United States of America , 2004, 20,101(3):737-42.
  DOI: 10.1073/pnas.0307757100
  pubMed: 14718664

  9913349

  CHEMBL516093