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hemiasterlin C


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  • Norine ID: NOR00459
  • DOI: 10.26097/nor00459
  • Family: hemiasterlin
  • Synonym(s): hemiasterlin C;
  • Activity: antitumor, toxin
  • Category: peptide
  • Formula: C29H44N4O4
  • Monoisotopic mass: 512.336255916 g/mol
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
  • Type: linear
  • Number of monomers: 3
  • Smiles: CNC(C(=O)NC(C(C)C)C(=O)N(C)C(C=C(C)C(=O)O)C(C)C)C(C)(C)c2cn(C)c1ccccc12

  • Graph inference:



  • Monomeric composition :
    1
    bbNMe-NMe-Trp
    2
    Val
    3
    NMe-hv-Val
  • Graph representation: bbNMe-NMe-Trp,Val,NMe-hv-Val @1 @0,2 @1

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Auletta sp.

  • Siphonochalina spp.

  • Links between organisms producing the hemiasterlin C: Auletta sp., Siphonochalina spp.
  • Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges
    Hamel E, Boyd MR, Gamble WR, Durso NA, Fuller RW, Westergaard CK, Johnson TR, Sackett DL, Cardellina JH, Bioorganic and medicinal chemistry , 1999, Aug,7(8):1611-5.
    DOI: 10.1016/s0968-0896(99)00089-9
    pubMed: 10482453


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