Norine

• Norine ID: NOR01129
• DOI: 10.26097/nor01129
• Family: triostin
• Synonym(s): triostin A;
• Activity: antimicrobial, antitumor
• Category: peptide
• Formula: C50H62N12O12S2
• Monoisotopic mass: 1086.405156908 g/mol
• Comment: Quinomycins contain a thioacetal cross bridge. In the tiostin analogues, a disulfide bond replaces the thioacetal cross-link.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: partial cyclic
• Number of monomers: 10
• Smiles: CC(C)C3C(=O)OCC(NC(=O)c1cnc2ccccc2(n1))C(=O)NC(C)C(=O)N(C)C4CSSCC(C(=O)N3(C))N(C)C(=O)C(C)NC(=O)C(COC(=O)C(C(C)C)N(C)C4(=O))NC(=O)c5cnc6ccccc6(n5)
  
  
• Graph inference:


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• Monomeric composition and PDB SEQRES:

  1 2 COOH-Qui D-Ser 0 QDS

  3 Ala 1 ALA

  4 NMe-Cys 2 NCY

  5 NMe-Val 3 MVA

  6 7 D-Ser COOH-Qui 4 QDS

  8 Ala 5 ALA

  9 NMe-Cys 6 NCY

  10 NMe-Val 7 MVA

• Graph representation: COOH-Qui,D-Ser,Ala,NMe-Cys,NMe-Val,D-Ser,COOH-Qui,Ala,NMe-Cys,NMe-Val @1 @0,2,9 @1,3 @2,4,8 @3,5 @4,6,7 @5 @5,8 @3,7,9 @1,8
  
  
• Atomic structure:

vizualisation:

• Streptomyces sp.
• gram: positive
• synonyms:
• taxid: 1931 (view NCBI taxonomy browser)

• Links between organisms producing the triostin A: Streptomyces sp.

• Structure confirmation of triostin a by 1H and 13C magnetic resonance
  Shoji J, Otsuka H, Kawano K, Kyogoku Y, The Journal of antibiotics , 1976, Jan,29(1):107-10.
  DOI: 10.7164/antibiotics.29.107
  pubMed: 931789

  316447

  CHEMBL2007041

  1vs2 2da8 185d

  1vs2 2da8 185d

  1vs2 2da8 185d