Norine

• Norine ID: NOR00689
• DOI: 10.26097/nor00689
• Family: orienticin
• Synonym(s): chloroorienticin C;
• Activity: antimicrobial
• Category: glycopeptide
• Formula: C60H65Cl2N9O19
• Monoisotopic mass: 1285.377376363 g/mol
• Comment: Two bonds of the central Hpg are due to oxidative ring closure.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: other
• Number of monomers: 8
• Smiles: CNC(CC(C)C)C(=O)NC2C(=O)NC(CC(N)=O)C(=O)NC6c3cc(Oc1ccc(cc1Cl)C2(O))c(O)c(c3)Oc4ccc(cc4Cl)C(OC5CC(C)(N)C(O)C(C)O5)C8NC(=O)C(NC6(=O))c7ccc(O)c(c7)c9c(O)cc(O)cc9(C(NC8(=O))C(=O)O)
  
  
• Graph inference:


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• Monomeric composition :

  1 Asn

  2 bOH-Cl-Tyr

  3 NMe-Leu

  4 Hpg

  5 bOH-Cl-Tyr

  6 Ere

  7 Dhpg

  8 Hpg

• Graph representation: Asn,bOH-Cl-Tyr,NMe-Leu,Hpg,bOH-Cl-Tyr,Ere,Dhpg,Hpg @1,3 @0,2,3 @1 @1,4,7,0 @3,5,6,7 @4 @4,7 @6,3,4
  
  
• Atomic structure:

vizualisation:

• Nocardia orientalis
• gram: positive
• synonyms: Amycolatopsis orientalis,Streptomyces orientalis,Amycolatopsis orientalis orientalis
• taxid: 31958 (view NCBI taxonomy browser)

• Links between organisms producing the chloroorienticin C: Nocardia orientalis

• New glycopeptide antibiotics: II. The isolation and structures of chloroorienticins
  Kobayashi M, Tsuji N, Kamigauchi T, Terui Y, The Journal of antibiotics , 1988, Oct,41(10):1506-10.
  DOI: 10.7164/antibiotics.41.1506
  pubMed: 3272137

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