Norine

• Norine ID: NOR00137
• DOI: 10.26097/nor00137
• Family: microcystin
• Synonym(s): [D-Asp3.ADMAdda5]microcystin-LHar;
• Activity: toxin
• Category: PK-NRP
• Formula: C50H74N10O13
• Monoisotopic mass: 1022.543682504 g/mol
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: cyclic
• Number of monomers: 7
• Smiles: CC(C)CC2NC(=O)C(C)NC(=O)C(=C)N(C)C(=O)CCC(NC(=O)C(C)C(C=CC(C)=CC(C)C(Cc1ccccc1)OC(C)=O)NC(=O)C(CCCCN=C(N)N)NC(=O)CC(NC2(=O))C(=O)O)C(=O)O
  
  
• Graph inference:


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• Monomeric composition :

  1 D-Ala

  2 Leu

  3 D-Asp

  4 Har

  5 ADMAdda

  6 D-Glu

  7 NMe-Dha

• Graph representation: D-Ala,Leu,D-Asp,Har,ADMAdda,D-Glu,NMe-Dha @1,6 @0,2 @1,3 @2,4 @3,5 @4,6 @0,5
  
  
• Atomic structure:

vizualisation:

• Nostoc
• gram: negative
• synonyms: Amorphonostoc
• taxid: 1177 (view NCBI taxonomy browser)

• Links between organisms producing the [D-Asp3.ADMAdda5]microcystin-LHar: Nostoc

• Three new microcystins, cyclic heptapeptide hepatotoxins, from Nostoc sp. strain 152
  Sivonen K, Namikoshi M, Evans WR, Carmichael WW, Rinehart KL, Fardig M, Chemical research in toxicology , 1992, Jul-Aug,5(4):464-9.
  pubMed: 1391612

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