Norine

• Type:
• Smiles: CSC1SCC2N(C)C(=O)C(C)NC(=O)C(COC(=O)C(N(C(=O)C1N(C)C(=O)C(C)NC(=O)C(COC(=O)C(N(C2=O)C)C(C)C)NC(=O)c1cnc2c(n1)cccc2)C)C(C)C)NC(=O)c1cnc2c(n1)cccc2
  
  
• Graph inference:


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• Atomic structure:

vizualisation:

• Streptomyces echinatus
• gram: positive
• taxid: 67293 (view NCBI taxonomy browser)

• Streptomyces
• gram: positive
• taxid: 68187 (view NCBI taxonomy browser)

• Links between organisms producing the Quinomycin A: Streptomyces echinatus, Streptomyces

• Studies on antibiotic biosynthesis by protoplasts and resting cells of Streptomyces echinatus. Part II. Effect of chromophore precursors.
  Canadian journal of microbiology , 1986, 32(5):363-72
  DOI: 10.1139/m86-071
  pubMed: 3719457

• Phase II trial of echinomycin in patients with advanced or recurrent colorectal cancer.
  Cancer chemotherapy and pharmacology , 1994, 34(3):266-9
  DOI: 10.1007/bf00685088
  pubMed: 8004762

• Giant linear plasmids in Streptomyces: a treasure trove of antibiotic biosynthetic clusters.
  The Journal of antibiotics , 2011, 64(1):19-25
  DOI: 10.1038/ja.2010.146
  pubMed: 21139625

• Functional cross-talk between fatty acid synthesis and nonribosomal peptide synthesis in quinoxaline antibiotic-producing streptomycetes.
  The Journal of biological chemistry , 2005, 280(6):4339-49
  DOI: 10.1074/jbc.M411026200
  pubMed: 15569690

• In vitro characterization of echinomycin biosynthesis: formation and hydroxylation of L-tryptophanyl-S-enzyme and oxidation of (2S,3S) β-hydroxytryptophan.
  PloS one , 2013, 8(2):e56772
  DOI: 10.1371/journal.pone.0056772
  pubMed: 23437232

• Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus.
  Biotechnology progress , 2008, 24(6):1226-31
  DOI: 10.1002/btpr.34
  pubMed: 19194935

• Frequent loss and restoration of antibiotic production by Streptomyces lasaliensis.
  The Journal of antibiotics , 1988, 41(5):624-37
  DOI: 10.7164/antibiotics.41.624
  pubMed: 3384750

• Echinomycin: the first bifunctional intercalating agent in clinical trials.
  Investigational new drugs , 1985, 3(4):403-10
  pubMed: 3910610

• Directed biosynthesis of novel derivatives of echinomycin by Streptomyces echinatus. I. Effect of exogenous analogues of quinoxaline-2-carboxylic acid on the fermentation.
  Canadian journal of microbiology , 1984, 30(4):439-50
  DOI: 10.1139/m84-065
  pubMed: 6744120

• Recognition elements that determine affinity and sequence-specific binding to DNA of 2QN, a biosynthetic bis-quinoline analogue of echinomycin.
  Anti-cancer drug design , 1999, 14(3):291-303
  pubMed: 10500504

• Influence of isoleucine upon quinomycin biosynthesis by Streptomyces sp. 732.
  Journal of bacteriology , 1967, 93(4):1327-31
  pubMed: 6032510

• Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product.
  Journal of the American Chemical Society , 2009, 131(26):9347-53
  DOI: 10.1021/ja902261a
  pubMed: 19514719

• [Coculture of actinomycetes with Bacillus subtilis and its effect on the bioactive secondary metabolites].
  Sheng wu gong cheng xue bao = Chinese journal of biotechnology , 2009, 25(6):932-40
  pubMed: 19777825

• Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.
  Nature Chemical Biology , 2006, 2(8):423-8
  DOI: 10.1038/nchembio803
  pubMed: 16799553

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