galacardin B
- Norine ID: NOR00934
- DOI: 10.26097/nor00934
- Family: galacardin
- Synonym(s): galacardin B;
- Activity: antimicrobial
- Category: glycopeptide
- Formula: C95H111Cl2N9O41
- Monoisotopic mass: 2103.625449519 g/mol
- Comment: They showed strong antimicrobial activity against Gram-positive bacteria and also showed excellent in vivo protective activity against Staphylococcus aureus infection in mice. Two bonds of the central Hpg are due to oxidative ring closure reactions.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: other
- Number of monomers: 13
- Smiles: CC1C(C(CC(O1)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C7C(=O)NC(C8=CC(=CC(=C8C9=C(C=CC(=C9)C(C(=O)N7)NC(=O)C5NC(=O)C(NC(=O)C(C(C1=CC=C(O4)C=C1)OC1C(C(C(C(O1)CO)O)O)O)NC(=O)C(C1=CC=C(C=C1)OC1C(C(C(C(O1)C)OC1C(C(C(C(O1)CO)O)O)O)O)O)NC)C1=CC(=C(C=C1)O)Cl)O)O)O)C(=O)O)OC1CC(C(C(O1)C)O)N)Cl)CO)O)O)N)O
- Graph inference:
- Monomeric composition :
1 NMe-Hpg 2 D-Gal 3 Rha 4 bOH-Tyr 5 D-Man 6 Hpg 7 Cl-Hpg 8 bOH-Cl-Tyr 9 Dhpg 10 Hpg 11 Ria 12 Ria 13 D-Glc - Graph representation: NMe-Hpg,D-Gal,Rha,bOH-Tyr,D-Man,Hpg,Cl-Hpg,bOH-Cl-Tyr,Dhpg,Hpg,Ria,Ria,D-Glc @3,1 @0,2 @1 @5,6,4,0 @3 @3,6,7,9,10 @3,5 @5,9,8,11 @9,7 @5,7,8 @5,12 @7 @10
- Atomic structure:
- Saccharothrix
- gram: positive
- taxid: 2071 (view NCBI taxonomy browser)
- Links between organisms producing the galacardin B: Saccharothrix
- Galacardins A and B, new glycopeptide antibiotics
Nakamura T, Inukai M, Katayama T, Takahashi S, Takeuchi M, Enokita R, Sakaida Y, Haruyama H, The Journal of antibiotics , 1992, Mar,45(3):297-305.
DOI: 10.7164/antibiotics.45.297
pubMed: 1577657
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