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polydiscamide C


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  • Norine ID: NOR00841
  • DOI: 10.26097/nor00841
  • Family: polydiscamide
  • Synonym(s): polydiscamide C;
  • Activity: antiinflammatory
  • Category: peptide
  • Formula: C74H108BrN18O21S
  • Monoisotopic mass: 1695.684051308 g/mol
  • Comment: Polydiscamides are putative NRPS products (no synthetase genes identified).
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
  • Type: partial cyclic
  • Number of monomers: 13
  • Smiles: CCC(C)(C)C(NC(=O)C(NC(=O)C2CCCN2(C(=O)C(Cc1ccc(cc1)Br)NC(=O)C(C)NC=O))C(C)C)C(=O)NC(Cc3c[nH]c4ccccc34)C(=O)NC(CCCN=C(N)N)C(=O)NC(CS(=O)(=O)O)C(=O)NC5C(C)OC(=O)C(CC(=O)O)NC(=O)C6CCCN6(C(=O)C(NC(=O)C(CCC(N)=O)N(C)C5(=O))C(C)C)

  • Graph inference:



  • Monomeric composition :
    1
    D-NFo-Ala
    2
    Br-Phe
    3
    Pro
    4
    D-Val
    5
    bMe-Ile
    6
    D-Trp
    7
    Arg
    8
    D-CysA
    9
    Thr
    10
    NMe-Gln
    11
    D-Val
    12
    Pro
    13
    D-Asp
  • Graph representation: D-NFo-Ala,Br-Phe,Pro,D-Val,bMe-Ile,D-Trp,Arg,D-CysA,Thr,NMe-Gln,D-Val,Pro,D-Asp @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9,12 @8,10 @9,11 @10,12 @8,11

  • Atomic structure:
    • Chemical structure
    rBAN vizualisation:
  • Ircinia
  • taxid: 275431 (view NCBI taxonomy browser)

  • Links between organisms producing the polydiscamide C: Ircinia
  • Polydiscamides B-D from a marine sponge Ircinia sp. as potent human sensory neuron-specific G protein coupled receptor agonists
    Feng Y, Carroll AR, Pass DM, Archbold JK, Avery VM, Quinn RJ, Journal of natural products , 2008, Jan,71(1):8-11.
    DOI: 10.1021/np070094r
    pubMed: 18163586


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