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cyclolithistide A


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  • Norine ID: NOR00444
  • DOI: 10.26097/nor00444
  • Family: cyclolithistide
  • Synonym(s): cyclolithistide A;
  • Activity: antimicrobial
  • Category: peptide
  • Formula: C54H86ClN11O15
  • Monoisotopic mass: 1163.5993388470001 g/mol
  • Comment: Cyclolithistide A is a putative NRPS product (no synthetase genes identified).
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
  • Type: partial cyclic
  • Number of monomers: 10
  • Smiles: CCC[C@H]1C(=O)OC(C(C(CC(=O)N[C@H](C(=O)N([C@H](C(=O)NC(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N1)CC2=CC=CC=C2)[C@H](C)O)CCC(=O)N)C(C)C(C)Cl)CC(C)C)C)C)O)NC(=O)[C@@H](CC(C)C)NC=O)C

  • Graph inference:



  • Monomeric composition :
    1
    Nva
    2
    Gly
    3
    Phe
    4
    aThr
    5
    Gln
    6
    Cl-Ile
    7
    NMe-Leu
    8
    Ala
    9
    C6:0-OH(3.5)-NH2(4)
    10
    NFo-Leu
  • Graph representation: Nva,Gly,Phe,aThr,Gln,Cl-Ile,NMe-Leu,Ala,C6:0-OH(3.5)-NH2(4),NFo-Leu @1,8 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @0,7,9 @8

  • Atomic structure:
    • Chemical structure
    rBAN vizualisation:
  • Theonella swinhoei
  • taxid: 37505 (view NCBI taxonomy browser)

  • Links between organisms producing the cyclolithistide A: Theonella swinhoei
  • An antifungal cyclodepsipeptide, cyclolithistide A, from the sponge Theonella swinhoei
    Clark DP, Carroll J, Naylor S, Crews P, Journal of Organic Chemistry , 1998, 63 (24), pp. 8757-8764


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