daptomycin
- Norine ID: NOR00001
- DOI: 10.26097/nor00001
- Family: daptomycin
- Synonym(s): daptomycin;
- Activity: antimicrobial
- Category: lipopeptide
- Formula: C72H101N17O26
- Monoisotopic mass: 1619.710366489 g/mol
- Comment: A21978C is a complex of lipopeptides which differ on their fatty acid moiety. It is used to treat complicated skin infections.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: partial cyclic
- Number of monomers: 14
- Smiles: CCCCCCCCCC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(N)=O)C(=O)NC(CC(=O)O)C(=O)NC4C(C)OC(=O)C(CC(=O)c3ccccc3(N))NC(=O)C(NC(=O)C(CO)NC(=O)CNC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCCN)NC(=O)CNC4(=O))C(C)CC(=O)O
- Graph inference:
- Monomeric composition :
1 C10:0 2 Trp 3 D-Asn 4 Asp 5 Thr 6 Gly 7 Orn 8 Asp 9 D-Ala 10 Asp 11 Gly 12 D-Ser 13 3Me-Glu 14 Kyn - Graph representation: C10:0,Trp,D-Asn,Asp,Thr,Gly,Orn,Asp,D-Ala,Asp,Gly,D-Ser,3Me-Glu,Kyn @1 @0,2 @1,3 @2,4 @3,5,13 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @4,12
- Atomic structure:
- Streptomyces roseosporus
- gram: positive
- synonyms: Streptomyces filamentosus,Streptomyces venezuelae subsp. roseospori,Streptomyces roseisporus
- taxid: 67294 (view NCBI taxonomy browser)
- Links between organisms producing the daptomycin: Streptomyces roseosporus
- A21978C, a complex of new acidic peptide antibiotics: isolation, chemistry, and mass spectral structure elucidation
Debono M, Barnhart M, Carrell CB, Hoffmann JA, Occolowitz JL, Abbott BJ, Fukuda DS, Hamill RL, Biemann K, Herlihy WC, The Journal of antibiotics , 1987, Jun,40(6):761-77.
DOI: 10.7164/antibiotics.40.761
pubMed: 3610833
- Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry
Baltz RH, Miao V, Wrigley SK, Coeffet-Legal MF, Brian P, Brost R, Penn J, Whiting A, Martin S, Ford R, Parr I, Bouchard M, Silva CJ, Microbiology , 2005, May,151(Pt 5):1507-23.
DOI: 10.1099/mic.0.27757-0
pubMed: 15870461
- Biosynthesis and genetic engineering of lipopeptide antibiotics related to daptomycin
Baltz RH, Current topics in medicinal chemistry , 2008, 8(8):618-38
DOI: 10.2174/156802608784221497
pubMed: 18473888
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