Norine
phakellistatin 12
- Norine ID: NOR00534
- DOI: 10.26097/nor00534
- Family: phakellistatin
- Synonym(s):
phakellistatin 12;
- Activity: antitumor
- Category:
peptide
- Formula: C60H86N10O12
- Monoisotopic mass: 1138.6426682659999 g/mol
- Comment: Phakellistatins are putative NRPS products (no synthetase genes identified)
- Source: norine
- Contributor (creation): Norine Team
[CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- Type: cyclic
- Number of monomers: 10
- Smiles: CCC(C)C3NC(=O)C7CCCN7(C(=O)C6CCCN6(C(=O)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C5CCCN5(C(=O)C4CCCN4(C(=O)C(CC(C)C)NC(=O)C(NC(=O)C(Cc2ccccc2)NC3(=O))C(C)O)))C(C)CC))
- Graph inference:
- Monomeric composition :
- Graph representation: Ile,Phe,Thr,Leu,Pro,Pro,Tyr,Ile,Pro,Pro @1,9 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @0,8
- Atomic structure:
vizualisation:
- Links between organisms producing the phakellistatin 12: Phakellia sp.
- Antineoplastic agents 390. Isolation and structure of phakellistatin 12 from a Chuuk archipelago marine sponge
Pettit GR,
Tan R,
Bioorganic and medicinal chemistry letters , 2003, Feb 24,13(4):685-8.
DOI: 10.1016/s0960-894x(02)01054-5
pubMed: 12639558
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