aciculitin B
- Norine ID: NOR00718
- DOI: 10.26097/nor00718
- Family: aciculitin
- Synonym(s): aciculitin B;
- Activity: antimicrobial, toxin
- Category: glycopeptide
- Formula: C62H88N14O21
- Monoisotopic mass: 1364.6248459479998 g/mol
- Comment: Aciculitins are putative NRPS products (no synthetase genes identified).
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: putative - change status to non-NRP (Norine validators only)
- last modification date: 2018-09-12 by Mickael Chevalier [Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- view all entry history
- Type: double cyclic
- Number of monomers: 11
- Smiles: CCCCCCCC=CC=CC(OC1OCC(O)C(O)C1(O))C(O)C(=O)NC(=CC)C(=O)NC4C(C)NC(=O)C5Cc2[nH]cnc2c3cc(ccc3(O))CC(NC(=O)C(NC4(=O))C(C)O)C(=O)NC(=CC)C(=O)NC(C(O)CC(N)=O)C(=O)NCC(=O)NC(CCC(N)=O)C(=O)N5
- Graph inference:
- Monomeric composition :
1 aThr 2 Tyr 3 dhAbu 4 bOH-Gln 5 Gly 6 Gln 7 His 8 Dab 9 C14:2(t4.t6)-OH(2.3) 10 Lyx 11 dhAbu - Graph representation: aThr,Tyr,dhAbu,bOH-Gln,Gly,Gln,His,Dab,C14:2(t4.t6)-OH(2.3),Lyx,dhAbu @7,1 @0,2,6 @1,3 @2,4 @3,5 @4,6 @7,5,1 @10,0,6 @9,10 @8 @8,7
- Atomic structure:
- Aciculites orientalis
- taxid: 1562474 (view NCBI taxonomy browser)
- Links between organisms producing the aciculitin B: Aciculites orientalis
- Aciculitins A-C: Cytotoxic and antifungal cyclic peptides from the lithistid sponge Aciculites orientalis
Williams DH, Faulkner DJ, Bewley CA, He H, Journal of the American Chemical Society , 1996, 118 (18), pp. 4314-4321
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