cephaibol A
- Norine ID: NOR00969
- DOI: 10.26097/nor00969
- Family: cephaibol
- Synonym(s): cephaibol A;
- Activity: antimicrobial
- Category: peptaibol
- Formula: C82H127N17O20
- Monoisotopic mass: 1669.944329589 g/mol
- Comment: The striking biological property of cephaibol A is its pronounced anthelmintic action and activity against ectoparasites.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: linear
- Number of monomers: 16
- Smiles: CC[C@@](C)(C(=O)NC(C)(C)C(=O)N1CC(C[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@](C)(CC)C(=O)N2CC(C[C@H]2C(=O)NC(C)(C)C(=O)N3CCC[C@H]3C(=O)NC(CC4=CC=CC=C4)CO)O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](CC5=CC=CC=C5)NC(=O)C
- Graph inference:
- Monomeric composition and PDB SEQRES:
1 Ac-Phe 1 2 ACE PHE gra2 Aib 3 AIB 3 Aib 4 AIB 4 Aib 5 AIB 5 Aib 6 AIB 6 Gly 7 GLY 7 Leu 8 LEU 8 D-Ival 9 DIV 9 Aib 10 AIB 10 4OH-Pro 11 HYP 11 Gln 12 GLN 12 D-Ival 13 DIV 13 4OH-Pro 14 HYP 14 Aib 15 AIB 15 Pro 16 PRO 16 Pheol 17 PHL - Graph representation: Ac-Phe,Aib,Aib,Aib,Aib,Gly,Leu,D-Ival,Aib,4OH-Pro,Gln,D-Ival,4OH-Pro,Aib,Pro,Pheol @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @12,14 @13,15 @14
- Atomic structure:
- Acremonium tubakii
- taxid: 146077 (view NCBI taxonomy browser)
- Links between organisms producing the cephaibol A: Acremonium tubakii
- Cephaibols, new peptaibol antibiotics with anthelmintic properties from Acremonium tubakii DSM 12774
Kim JH, Schiell M, Hofmann J, Kurz M, Schmidt FR, Vogel M, Wink J, Seibert G, The Journal of antibiotics , 2001, Mar,54(3):220-33.
DOI: 10.7164/antibiotics.54.220
pubMed: 11372779
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