Norine

• Norine ID: NOR00296
• DOI: 10.26097/nor00296
• Family: friulimicin
• Synonym(s): friulimicin A;
• Activity: antimicrobial
• Category: lipopeptide
• Formula: C58H92N14O19
• Monoisotopic mass: 1288.666316832 g/mol
• Comment: The acyl residue is essential for antibiotic activity.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: partial cyclic
• Number of monomers: 12
• Smiles: C[C@@H]1[C@@H](C(=O)N2CCCC[C@@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C(=O)N[C@@H](C(=O)N3CCC[C@H]3C(=O)N1)C(C)C)[C@@H](C)N)CC(=O)O)CC(=O)O)[C@H](C)C(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)C/C=C\CCCCCCC(C)C
  
  
• Graph inference:


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• Monomeric composition :

  1 iC13:1(3)	2 Asn	3 L-Dbu	4 Hpr	5 bMe-Asp	6 Asp	7 Gly	8 Asp	9 Gly	10 D-Dbu	11 Val	12 Pro

• Graph representation: iC13:1(3),Asn,L-Dbu,Hpr,bMe-Asp,Asp,Gly,Asp,Gly,D-Dbu,Val,Pro @1 @0,2 @1,3,11 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @2,10
  
  
• Atomic structure:

vizualisation:

• Actinoplanes friuliensis
• gram: positive
• taxid: 196914 (view NCBI taxonomy browser)

• Links between organisms producing the friulimicin A: Actinoplanes friuliensis

• An acyl-CoA dehydrogenase is involved in the formation of the Delta cis3 double bond in the acyl residue of the lipopeptide antibiotic friulimicin in Actinoplanes friuliensis
  Heinzelmann E, Berger S, Muller C, Hartner T, Poralla K, Wohlleben W, Schwartz D, Microbiology , 2005, Jun,151(Pt 6):1963-74.
  DOI: 10.1099/mic.0.27844-0
  pubMed: 15942003

• Sequencing and analysis of the biosynthetic gene cluster of the lipopeptide antibiotic Friulimicin in Actinoplanes friuliensis
  Heinzelmann E, Muller C, Wohlleben W, Schwartz D, Puk O, Nolden S, Gebhardt P, Lange C, Welzel K, Antimicrobial agents and chemotherapy , 2007, Mar,51(3):1028-37.
  DOI: 10.1128/AAC.00942-06
  pubMed: 17220414

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