Norine

• Norine ID: NOR00241
• DOI: 10.26097/nor00241
• Family: actinomycin
• Synonym(s): actinomycin pip1-beta;
• Activity: antimicrobial
• Category: chromopeptide
• Formula: C63H88N12O16
• Monoisotopic mass: 1268.6441248279998 g/mol
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: double cyclic
• Number of monomers: 11
• Smiles: CC(C)C6NC(=O)C(NC(=O)C4=C(N)C(=O)C(C)=C3Oc5c(C)ccc(C(=O)NC1C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2(C(=O)C(NC1(=O))C(C)C))c5(N=C34))C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C7CCCCN7(C6(=O))
  
  
• Graph inference:


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• Monomeric composition :

  1 D-Val

  2 Hpr

  3 NMe-Gly

  4 NMe-Val

  5 Thr

  6 ChrAct

  7 Thr

  8 D-Val

  9 Pro

  10 NMe-Gly

  11 NMe-Val

• Graph representation: D-Val,Hpr,NMe-Gly,NMe-Val,Thr,ChrAct,Thr,D-Val,Pro,NMe-Gly,NMe-Val @1,4 @0,2 @1,3 @2,4 @0,3,5 @4,6 @5,7,10 @6,8 @7,9 @8,10 @6,9
  
  
• Atomic structure:

vizualisation:

• Streptomyces antibioticus
• gram: positive
• synonyms: Actinomyces antibioticus
• taxid: 1890 (view NCBI taxonomy browser)

• Links between organisms producing the actinomycin pip1-beta: Streptomyces antibioticus

• Isolation, purification, and characterization of pipecolic acid-containing actinomycins, Pip 2, Pip 1 alpha, and Pip 1 beta
  Katz E, Formica JV, The Journal of biological chemistry , 1973, Mar 25,248(6):2066-71.
  pubMed: 4120478

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