Norine

• Norine ID: NOR00844
• DOI: 10.26097/nor00844
• Family: ramoplanin
• Synonym(s): ramoplanin A2;
• Activity: antimicrobial
• Category: lipopeptide , glycopeptide
• Formula: C119H154ClN21O40
• Monoisotopic mass: 2552.035046623 g/mol
• Comment: Ramoplanin factors A1, A2, and A3 were isolated in 12, 72, and 16% yields, respectively, from purification of the culture broth of Actinoplanes strain ATCC 33076.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: partial cyclic
• Number of monomers: 20
• Smiles: CC(C)CC=CC=CC(=O)NC(CC(N)=O)C(=O)NC%10C(=O)NC(c1ccc(O)cc1)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(c2ccc(O)cc2)C(=O)NC(c3ccc(O)cc3)C(=O)NC(C(C)O)C(=O)NC(Cc4ccccc4)C(=O)NC(CCCN)C(=O)NC(c5ccc(cc5)OC7OC(CO)C(O)C(O)C7(OC6OC(CO)C(O)C(O)C6(O)))C(=O)NC(C(C)O)C(=O)NC(c8ccc(O)cc8)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(c9ccc(O)c(c9)Cl)C(=O)OC%10(C(N)=O)
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 iC9:2(2.t4)	2 Asn	3 OH-Asn	4 D-Hpg	5 D-Orn	6 D-aThr	7 Hpg	8 D-Hpg	9 aThr	10 Phe	11 D-Orn	12 Hpg
  13 D-Man	14 D-Man	15 D-aThr	16 Hpg	17 Gly	18 Leu	19 D-Ala	20 Cl-Hpg

• Graph representation: iC9:2(2.t4),Asn,OH-Asn,D-Hpg,D-Orn,D-aThr,Hpg,D-Hpg,aThr,Phe,D-Orn,Hpg,D-Man,D-Man,D-aThr,Hpg,Gly,Leu,D-Ala,Cl-Hpg @1 @0,2 @1,3,19 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12,14 @11,13 @12 @11,15 @14,16 @15,17 @16,18 @17,19 @2,18
  
  
• Atomic structure:

vizualisation:

• Actinoplanes sp.
• gram: positive
• synonyms: Ampullariella sp.
• taxid: 1871 (view NCBI taxonomy browser)

• Links between organisms producing the ramoplanin A2: Actinoplanes sp.

• Chemistry and biology of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity
  Walker S, Chen L, Hu Y, Rew Y, Shin D, Boger DL, Chemical reviews , 2005, Feb,105(2):449-76.
  DOI: 10.1021/cr030106n
  pubMed: 15700952

• Chemistry and biology of the ramoplanin family of peptide antibiotics
  McCafferty DG, Cudic P, Frankel BA, Barkallah S, Kruger RG, Li W, Biopolymers , 2002, 66(4):261-84.
  DOI: 10.1002/bip.10296
  pubMed: 12491539

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