ramoplanin A2
- Norine ID: NOR00844
- DOI: 10.26097/nor00844
- Family: ramoplanin
- Synonym(s): ramoplanin A2;
- Activity: antimicrobial
- Category: lipopeptide , glycopeptide
- Formula: C119H154ClN21O40
- Monoisotopic mass: 2552.035046623 g/mol
- Comment: Ramoplanin factors A1, A2, and A3 were isolated in 12, 72, and 16% yields, respectively, from purification of the culture broth of Actinoplanes strain ATCC 33076.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: partial cyclic
- Number of monomers: 20
- Smiles: CC(C)CC=CC=CC(=O)NC(CC(N)=O)C(=O)NC%10C(=O)NC(c1ccc(O)cc1)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(c2ccc(O)cc2)C(=O)NC(c3ccc(O)cc3)C(=O)NC(C(C)O)C(=O)NC(Cc4ccccc4)C(=O)NC(CCCN)C(=O)NC(c5ccc(cc5)OC7OC(CO)C(O)C(O)C7(OC6OC(CO)C(O)C(O)C6(O)))C(=O)NC(C(C)O)C(=O)NC(c8ccc(O)cc8)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(c9ccc(O)c(c9)Cl)C(=O)OC%10(C(N)=O)
- Graph inference:
- Monomeric composition :
1 iC9:2(2.t4) 2 Asn 3 OH-Asn 4 D-Hpg 5 D-Orn 6 D-aThr 7 Hpg 8 D-Hpg 9 aThr 10 Phe 11 D-Orn 12 Hpg 13 D-Man 14 D-Man 15 D-aThr 16 Hpg 17 Gly 18 Leu 19 D-Ala 20 Cl-Hpg - Graph representation: iC9:2(2.t4),Asn,OH-Asn,D-Hpg,D-Orn,D-aThr,Hpg,D-Hpg,aThr,Phe,D-Orn,Hpg,D-Man,D-Man,D-aThr,Hpg,Gly,Leu,D-Ala,Cl-Hpg @1 @0,2 @1,3,19 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12,14 @11,13 @12 @11,15 @14,16 @15,17 @16,18 @17,19 @2,18
- Atomic structure:
- Actinoplanes sp.
- gram: positive
- synonyms: Ampullariella sp.
- taxid: 1871 (view NCBI taxonomy browser)
- Links between organisms producing the ramoplanin A2: Actinoplanes sp.
- Chemistry and biology of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity
Walker S, Chen L, Hu Y, Rew Y, Shin D, Boger DL, Chemical reviews , 2005, Feb,105(2):449-76.
DOI: 10.1021/cr030106n
pubMed: 15700952
- Chemistry and biology of the ramoplanin family of peptide antibiotics
McCafferty DG, Cudic P, Frankel BA, Barkallah S, Kruger RG, Li W, Biopolymers , 2002, 66(4):261-84.
DOI: 10.1002/bip.10296
pubMed: 12491539
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