Norine

• Norine ID: NOR00374
• DOI: 10.26097/nor00374
• Family: didemnin
• Synonym(s): didemnin B;
• Activity: antimicrobial, antitumor, immunomodulating
• Category: peptide
• Formula: C57H89N7O15
• Monoisotopic mass: 1111.641665213 g/mol
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: partial cyclic
• Number of monomers: 9
• Smiles: CCC(C)C3NC(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)C1CCCN1(C(=O)C(C)O))C(C)OC(=O)C(Cc2ccc(cc2)OC)N(C)C(=O)C4CCCN4(C(=O)C(CC(C)C)NC(=O)C(C)C(=O)C(OC(=O)CC3(O))C(C)C)
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 Ist

  2 Hip

  3 Leu

  4 Pro

  5 NMe-OMe-Tyr

  6 Thr

  7 D-NMe-Leu

  8 Pro

  9 Lac

• Graph representation: Ist,Hip,Leu,Pro,NMe-OMe-Tyr,Thr,D-NMe-Leu,Pro,Lac @1,5 @0,2 @1,3 @2,4 @3,5 @0,4,6 @5,7 @6,8 @7
  
  
• Atomic structure:

vizualisation:

• Trididemnum solidum
• gram:
• synonyms:
• taxid: 1079459 (view NCBI taxonomy browser)

• Didemnum sp.
• gram:
• synonyms:
• taxid: 107395 (view NCBI taxonomy browser)

• Links between organisms producing the didemnin B: Trididemnum solidum, Didemnum sp.

• Didemnin B induces apoptosis in proliferating but not resting peripheral blood mononuclear cells
  Baker MA, Grubb DR, Lawen A, Apoptosis : an international journal on programmed cell death , 2002, Oct,7(5):407-12.
  pubMed: 12207173

• Natural products as probes of cell biology: 20 years of didemnin research
  Vera MD, Joullie MM, Medicinal research reviews , 2002, Mar,22(2):102-45.
  pubMed: 11857636

  122651

  CHEMBL414042